Comparative envaluation of metals content of serum and subcutaneous interstitial fluid revealed that levels of chromium, manganese, arsenic, cadmium in these biologic media have no reliable differences (p = 0.056-0.907) but strong correlation (r = 0.52-0.93). Findings are that some metals (nickel, copper, zinc, lead) contents of subcutaneous interstitial fluid have reliable differences in contents of serum and subcutaneous interstitial fluid, but these metals have strong correlations between their contents in the biologic media (r = 0.43-0.72). Chances are that subcutaneous interstitial fluid is a promising medium for biomonitoring of dose load in metallurgic industry workers and enables to increase efficiency of measures reducing risk of occupational hazards influence on the workers' health.

The article deals with results of assessing risk of occupationally related hypertension among workers of sylvinitedressing works, with individual sensitivity consideration. Epidemiologic study proved correlation between occupational exposure to noise over 83 dB and hypertension and its predictors - increased activity of serum lipoprotein and homocystein. The studies determined an indicator of the workers' increased sensitivity to arterial hypertension development and to changes in parameters of disordered vascular tone regulation (increased activity of serum lipoprotein and homocystein) under exposure to noise - CT genotype of MTHFR gene. Workers with CT genotype of MTHFR gene, according to epidemiologic analysis, demonstrated increase in relative risk of vascular tone regulation disorders (hypertension predictor). Additional probability of vascular tone regulation disorders under exposure to noise of 83 dB in sylvinitedressing workers with increased individual sensitivity is estimated at 3%.

Workers of titanium and magnesium production, under occupational exposure to complex of chemical (chlorine, hydrochloride, sulfur dioxide) and physical factors (industrial noise, work hardiness), have arterial hypertension as occupationally related disease, when length of service over 15 years (EF = 71,5%), and nasopharyngitis for length of service over 10 years (EF = 65%). Arterial hypertension risk is mostly associated with increased industrial noise level (F = 1621; R2 = 0.95; p < 0,001; noise 70,1 dB). Mathematic modelling of nasopharyngitis development probability demonstrated dependence of concentration of chlorine, hydrochloride, sulfur dioxide, chlorine and hydrochloride combination (F = 37-281; R2 = 0,37-0,73; p < 0.001; chlorine 0,63 mg/m³). Complex of parameters (leucocytosis, eosinophilia, increased IgA level), activated cellular immunity (increased CD16+56+, CD3+CD25+) and absolute phagocytosis characterized nonspecific inflammatory reaction, immunity tension as a response to a complex of chemical factors of titanium and magnesium production. Markers of endothelial dysfunction and cardiovascular risk (uric acid, VEGF, homocystein, LDLP) and stress marker (cortisol) demonstrate potential effect of occupational factors on vascular wall, metabolic processes and central nervous system, with involvement of «pituitary - hypothalamus - adrenals» axis. Changes of these parameters in workers with long length of service indicate risk of occupationally related disease on preclinical stage.

Complex study of thyroid gland covered workers engaged into mechanical rubber production, under exposure to complex of occupational factors. Chemical analytic study revealed 5.5 times excess of acrylonitrile content of expired air in examinees of the study group if compared to the reference group. Ultrasound examination data demonstrate structural changes in thyroid gland in 72% of the workers (diffuse changes and nodular masses). As early dysadaptation markers, findings are 1.3-1.7 times increased antibodies to TPO and higher TSH level. These disorders can indicate autoimmune processes in thyroid tissue and strain of compensatory adaptational mechanisms of pituitary-thyroid regulation.

The authors demonstrate that work conditions for main occupations of sylvinite ore-dressing production (drying machine operator, granulation operator, drying and granulation dosage department operator, centrifuge operator, filtration operator, transporting machine operator in drying and granulation department, mill operator) are characterized by combined exposure to chemical and physical occupational hazards: formaldehyde, highly dispersed dust (PM_1,0), industrial noise, increased microclimate parameters. The work conditions are considered as hazardous (class 3.1, 3.2, 3.3). Findings are reliable increase of MDA level with lower general antioxidant defence in serum, when compared to the reference group. Increased homocysteine, lipoprotein with significant decreased nitrogen oxide production are seen. These processes can result in disordered structure and endothelial function of vessels, with higher prevalence of arterial hypertension. Values of MDA, antioxidant activity, homocysteine, lipoprotein (a), nitrogen oxide are justified as markers for early diagnosis of occupationally related arterial hypertension

Based on complex of parameters characterizing social economic level, innovation activity and morbidity among able-bodied population, the authors suggested a typology of RF regions different in potential, urgency and risk value of modernization. Claster analysis helped to identify 4 types of territories - moderately modernizing regions with high modernization potential (12 RF subjects), well modernizing regions with moderate modernization potential (26 RF subjects), moderately modernizing regions with moderate modernization potential (28 RF subjects), poorly modernizing regions with low modernization potential (5 RF subjects). Findings are that special attention is required not only by RF subjects with the workers' low health level and poorly modernization processes, but also highly modernized regions with the workers' health problems can result from risky character of modernization. The article is prepared with financial support from RGNF (project N 16-16-59007).

Occupational activity with night shifts and length of service over 5 years is characterized by prevalent sympathetic influence on cardiac activity, vagosympathetic interaction index (LF/HF) is considerably higher than in workers with lower length of service and 1.5 times exceeding upper normal value. VLF indicator exceeds physiologic normal value due to increased activity of ergotropic and humoral metabolic mechanisms of cardiac rhythm regulation. Sympathetic regulation activity level (LF parameter) is also reliably higher than in workers with lower length of service (p = 0.024). Parasympathetic regulation activity level (HF parameter) is below normal value - that indicates decreased influence of parasympathetic vegetative system on cardiac activity (depression of defence mechanisms). Comparative analysis of vegetative regulation spectrum at rest, in accordance with length of service, demonstrated the most marked changes in workers with length of service over 5 years: lower total spectral capacity (TP, ms²), lower share of high-frequency waves (HF, %), increase of average vagosympathetic interaction index (LF/HF) and higher share of very low waves (VLF, %) in the spectrum structure. The data prove intensified ergotropic, humoral, sympathetic influences on cardiac activity and, as a result, higher risk of dysmetabolic processes and cardiovascular diseases.

Clinical, laboratory and ultrasound examination covered features of lipid metabolism disorders in 137 adults and 170 children, neighbouring storage of ore-processing and extraction waste, in conditions of chronic exposure to metals from various sources (ambient air, water, foods). Findings are that children with higher serum levels of cadmium and arsenic (1.4-2.0 times vs. the reference group) demonstrated 2.2 times more frequent endocrine diseases, up to 2.7 times more frequent obesity related diseases, if compared to the reference group (OR = 2.74; DI = 1.05-7.14; p < 0.05). Chronic noncarcinogenous risk for endocrine system was characterized by jeopardy index (THI) 3.78 - unacceptable risk. With unacceptable risk due to multi-source exposure to lead, cadmium and arsenic, the findings are: dysfunction of hypothalamus-pituitary-thyroid link, with activated free radical oxidation and accumulation of perioxidation products, depletion of antioxidant defence resources, disorders of neuromediator processes and lipid metabolism, with obesity formation (ICD: E67.8-66.0), mostly related to negative influence of arsenic (r = 0.37-0.59; p = 0.004-0.05).

To evaluate occupational hazards for workers engaged into mechanical rubber production, the authors determined contents of acrylonitrile in serum and expired air, during occupational exposure and in reference group. Findings are that depending on occupation, age and length of service, acrylonitrile contamination level of expired air has intermittent effect. Main occupations workers are exposed to continuous inhalation of acrylonitrile vapors, with its average concentration of 0.01-0.015 mg/m³ in air of workplace. Acrylonitrile concentration in expired air of this group ranged from 0.0001-0.0009 mg/m³ - that is reliably (p <0.05) higher (5.5 times) than in expired air of the reference group members. Serum levels of acrylonitrile did not differ significantly between the main group and the reference group members.

Identification covered a source of dust deposits in snow on stationary monitoring sites near the largest in Europe copper-nickel enterprise «Kolskaya GMK». Retrospective analysis demonstrated that considerable decrease in aerotechnogenic load resulted in disappeared technogenic phase of the dust releases, but revealed influence of neighbouring heating power station using fuel oil.