The authors justified a method to evaluate and forecast risk of medical and demographic losses connected with influence of variable environmental factors on mortality and morbidity parameters among able-bodied population. Suggested methods and approaches were tested and exemplified by Far East and North Caucases regions orientated to advanced and modernization development strategies. Mathematic modelling results helped to characterize relationships between environmental and social economic risk factors with health responses. These factors appear to form annual probable regional losses varying from tens to over thousand of deaths among economically active individuals and up to several hundreds of disablement cases. Progressive labor deficit and worse health among economically active population appeared to be major obstacles on the way to modernization of Russian regions.

Forming a community at risk for circulatory system diseases will increase efficiency of medical and prophylactic measures on managing risk of arterial hypertension. Epidemiologic analysis helped to reveal reliable connection between arterial hypertension predictors and work conditions of mining machine operators and supported actualization of high occupational risk suggested in a priori evaluation. Mathematic modelling helped to forecast increase in the disease probability: with noise level of 94 dB after 10 years of work, 17.9% of workers are expected to have arterial hypertension preventing from further occupational activity. Forecasting results of arterial hypertension probability help to form risk groups for medical and preventive technologies managing occupational risk, and predictors enable to specify necessity of individual medical preventive measures.

Medical examination covered female workers engaged into chemical production of technical rubber goods, under combined exposure to chemicals (nitrogen oxides, carbon oxide) and noise exceeding MAC by 3.7-27.5%. Findings are increased phagocytary activity, lower level of serum IgM and IgG, suppressed expression of CD25 and CD95 T-cell receptors, and slower apoptosis induced via Fas receptor - all those indicators associated with work conditions. The disorders revealed are actualized on a basis of genetic variability features of the females, that is characterized by prevalence of mutant allels of FAS and TNFR genes with minor homozygous phenotype.

The article presents results of experimental study concerning acute inhalation toxicity of nanodispersed manganese oxide widely used in novelty goods production. During the technology process, nano-dimensional manganese oxide aerosol could appear in workplace air - that causes danger of the workers' inhalation exposure. Findings are that the studied substance is a nanomaterial with prevalent filiform particles measuring 15-29 nm. The substance is acutely toxic when inhaled as an aerosol. Cl₅₀ for 4-hour exposure for Wistar rats equals 120 mg/m³ (1 jeopardy class). Clinical manifestations of acute intoxication are mostly irritative and neurotoxic effects supported by morphologic studies. Histopathologic changes in brain tissue are cerebellar ischemia with dilated perecellular spaces, faveolate appearance.

The article covers results of preventive measures in workers engaged into underground mining. Those measures are aimed to prevent occupationally mediated health disorders resulting in circulatory diseases. The prophylaxis was proven effective on premorbid condition - that was demonstrated in reliable decrease of cause-effect relationship intensity for health disorders in workers subjected to prophylactic measures. Transitory disablement morbidity due to cicrulatory system diseases decreased. Situational modelling of risk changes for the studied group demonstrated changes of diseases risk under medical prophylactic measures. After the prophylaxis, the risk demonstrated 3.1 times decrease.

Comparative analysis covered immune genetic parameters in nonferrous metallurgy workers. The authors demonstrated differences in immune genetic profile between male and female workers, under exposure to combination of occupational hazards: noise and dust. Analysis of gene polymorphism revealed predominant disorders in the female workers, concerning criterion of prevalence for minor allele of genes in 1 and 2 phases of detoxication, neuro-endocrine regulation, lipid and energy metabolism, genes of immune regulation and apoptosis.

The authors demonstrated that work conditions for main occupations (puncher, cutter, sorter, melter) of titanium-magnesium production are characterized by combined exposure to chemical and physical environmental hazards: titanium oxide aerosol, industrial noise, local vibration, heating microclimate, work hardiness. The work conditions are assessed as hazardous (class 3.2-3.4), work process as hard (class 3.2). The female workers appeared to have reliable increased of AST and prolactine, with lower serum estradiol and FSH levels, if compared to reference group. The workers demonstrated increase in LH, SHBG, prolactine and estradiol, with decrease of free testosterone. That can result in reproductive disorders of men and women, as well as remote effects in offspring.

Evaluation of effects caused by environmental peroral exposure to chlorine organic compounds revealed that individuals with AG variation of HTR2A gene are a community with increased sensitivity to chloroform and a risk group for lipid and carbohydrates metabolism disorders. Individual risk of endocrine disorders (ICD: E67.8 excessive nutrition and E66.0 obesity) in these individuals is higher than in general population exposed to chloroform at residence (HQ1.72). Serum serotonin level, that is functionally connected with HTR2A gene, is 1.3 times lower vs. the reference group value.

The results of a retrospective dynamic monitoring in 1976-2014 of the workers of coal mines of main (n = 1732) and auxiliary (n = 1059) occupations, with diagnosed occupational sciatica (OS) in the center of occupational medicineare viewed. It was found that the workers of the main occupationson average of 3 years earlier than initially treated at the center of occupational medicine, and occupational disease OS sets for them 1.5-2 years earlier. The analysis of the formation of risk groups depending on the diagnosis and treatment of the primary analysis of the incidence of OS.

The authors evaluated adaptational potential of cardiovascular system in 110 police officers considered as apparently healthy and fit for service, working in psychoemotional stress with exertion of body adaptational functions and health disorders development. Adaptational potential of cardiovascular system served as an indicator of adaptive body reactions. Prenosologic states diagnosis determined risks of main general pathologic syndromes in individuals with satisfactory and disordered adaptation. Leading symptoms of emotional burnout were assessed and appeared to depict depletion of psychoemotional processes in occupational activity of individuals with various adaptation states. The study results enable to connect adaptation disorder with risk of main general pathologic syndromes and occurrence of emotional burnout symptoms. The prenosologic states appearing could be considered as an adaptation way towards specific conditions of occupational activity of police officers.

The results of the study to evaluate satisfaction with the quality of the periodic medical examinations of workers (PME) are analyzed. In survey 45 employers, 120 doctors performing PME and 107 workers participated. The results show low satisfaction with the quality of the PME. Employers in 60% of cases noted the formal conduct of PME. Doctors in 40,8% of cases as the main defect in the organization of PME mentioned the lack of quality control system. According to the workers' opinion, the poor quality of PME recognized in 30.8% of cases; however, 54.2% of the workers noted the good organization of the PME.