Introduction. It is relevant to study the adaptive changes among the participants of the Arctic marine expedition, which allow for a certain period of time to maintain a stable working capacity necessary to perform various professional tasks.

The study aims to identify the dynamics of hormonal parameters in saliva and blood serum samples of the expedition group members who temporarily come to work in the extreme conditions of the Arctic.

Materials and methods. Scientists examined 40 participants of the expedition of the Arctic Floating University: 24 women and 16 men aged from 19 to 56 years (the average age is 26 years). They collected saliva in the morning and evening at the beginning, middle and end of the 21-day route. Specialists performed blood sampling in the morning on an empty stomach at the beginning and at the end of the expedition. The levels of cortisol, dehydroepiandrosterone and testosterone were determined by enzyme immunoassay.

Results. The concentration of morning salivary cortisol is maximum at the beginning of the route for both men (32.2 nmol/l) and women (31.8 nmol/l), then it decreases significantly by the end of the expedition (8.2 and 8.7 nmol/l, respectively). The reverse dynamics is shown for evening cortisol levels: the maximum values at the end of the route compared with the beginning in men (6.6 versus 1.4 nmol/l) and women (5.5 versus 1.7 nmol/l). The content of morning and evening dehydroepiandrosterone is maximal in women at the beginning of the expedition, then decreases by the end of the route (1.52 and 0.91 nmol/l for morning concentrations, p<0.0001; 0.35 and 0.21 nmol/l for evening concentrations, p=0.013), while it does not significantly change in men. Testosterone levels increase in the middle of the route, more significantly in women (0.26 versus 0.05 nmol/l, p<0.0001). The content of serum hormone concentrations does not significantly change except for the level of dehydroepiandrosterone in men, whose level decreases by the end of the route (47.6 versus 65.4 nmol/l, p=0.038).

Limitations. Most of the participants did not have the opportunity to measure the background values of the indicators before the route, which, of course, would have been of great value.

Conclusion. The hormone content in saliva, rather than in serum, is an informative indicator reflecting hormonal changes in the body of participants in the Arctic expedition associated with the presence of acute stress caused by natural factors and specific working conditions. An increase in evening cortisol and testosterone levels indicates a violation of their circadian dynamics and the possible development of desynchronosis in the expedition members by the end of the route. An increase in dehydroepiandrosterone at the beginning of the expedition and testosterone from the middle of the route may indicate their adaptive and neuroprotective role under the influence of a complex of stressful conditions of the expedition and increased mental stress.

Ethics. The study was conducted in compliance with Ethical standards (Minutes No. 2 of the meeting of the Ethics Committee of the N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences dated 06.06.2024).

For citation: Elfimova A.E., Patyavina O.I., Zyabisheva V.N., Tipisova E.V. Hormonal parameters of saliva and blood of participants of the 21-day Arctic marine expedition. Med. truda i prom. ekol. 2025; 65(3): 132–141. https://elibrary.ru/zmsujf https://doi.org/10.31089/1026-9428-2025-65-3-132-141

Contributions:
Elfimova A.E. — concept and design of research, collection and processing of material, writing, editing;
Patyavina O.I. — collection and processing of material, statistical data processing;
Zyabisheva V.N. — material processing, text writing;
Tipisova E.V. — research concept and design, editing.

Gratitude. The authors express thanks to the Arctic Floating University project and the participants of this study, without whom it would not have taken place.

Funding. The study was conducted with the financial support of project No. 124052300054-6 under the Agreement of the Ministry of Economic Industry and Science of JSC No. 8 dated 04/17/2024.

Conflict of interest. The authors declare no conflict of interest.

Received: 03.05.2025 / Accepted: 19.03.2025 / Published: 07.04.2025

Introduction. Lead is one of the proven risk factors for developing cardiovascular diseases, which is determined by its effect on vascular tone, lipid and carbohydrate metabolism, as well as the activity of the inflammatory process, and therefore monitoring of metabolic parameters is an important component of preventive measures for workers in contact with lead and its compounds.

The study aims to analyze changes in carbohydrate and lipid metabolism in employees of a lead-acid battery processing plant to select informative markers for assessing cardiovascular risk.

Materials and methods. The main group consisted of 62 men working at a lead-acid battery recycling plant with 8 (4; 10) years of experience. The control group consisted of 30 men who worked outside of contact with harmful industrial factors. The laboratory examination included the determination of blood lead levels, ALA in urine, carbohydrate (glucose, insulin) and lipid (cholesterol (HC), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, apolipoproteins A1 and B, lipoprotein (a)) metabolism. Non-HDL cholesterol, atherogenicity index (IA), apo B/apo A1, TG/HDL cholesterol, metabolic index (MI), HOMA-IR were calculated.

Results. Compared with the control group, individuals in the main group showed lower levels of HDL cholesterol, apo A1, higher levels of insulin, HOMA-IR, and MI. Correlations with work experience were revealed in the absence of age dependence for HDL cholesterol (r=–0.35, p=0.006), IA (r=0.258, p=0.043), apo A1 (r=–0.313, p=0.013), apo B/apo A1 (r=0.287, p=0.024), MI (r=0.262, p=0.04). It has been shown that at least 10 years of service, the levels of HDL cholesterol, apo A1 are lower, and the levels of IA, apo B/apo A1, TG/HDL-C, MI are higher compared with employees with less experience. There is an average degree of relationship between HOMA-IR and indirect markers of insulin resistance of TG/HDL cholesterol (r=0.525, p<0.001) and MI (r=0.568, p<0.001).

Limitations. The study is limited to a sample of surveyed employees of a single lead-acid battery recycling facility.

Conclusion. The influence of exposure to harmful production factors of a lead-acid battery processing plant on the development of lipid and carbohydrate metabolism disorders is shown, which determines the importance of studying additional laboratory parameters (HDL cholesterol, triglycerides) in employees of these enterprises to objectify the assessment of metabolic processes.

Ethics. The study was conducted in compliance with Ethical standards for conducting medical research involving humans in accordance with the requirements of the Helsinki Declaration of the World Medical Association. The study was approved by the conclusion of the local Ethics Committee of Izmerov Research Institute of Occupational Health (protocol of the meeting of the Ethics Committee No. 5 dated 08/02/2023).

Contributions:
Kuzmina L.P. — research concept and design, editing;
Khotuleva A.G. — research concept and design, collection and processing of material, laboratory research, writing, editing;
Kolyaskina M.M. — conducting laboratory research, collecting and processing material, writing text;
Bezrukavnikova L.M. — concept and design of research, editing;
Kapralova O.A. — conducting laboratory tests.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 06.03.2025 / Accepted: 24.03.2025 / Published: 07.04.2025

Introduction. Under the influence of industrial vibration, disorders form in various body systems, including the central nervous system (CNS). It is advisable to detect changes in the structures of the nervous system by conducting electroneuromyography (ENMG) with testing of sensory and motor axons with F-wave registration, determination of somatosensory evoked potentials, peripheral transcranial magnetic stimulation.

The study aims to provide a comprehensive assessment of the structures of the nervous system (peripheral nerves, spinal cord neurons, thalamic region, cortical representation) in patients with vibration disease associated with the combined effects of local and general vibration.

Materials and methods. 36 patients with vibration disease were examined, with an average age of 54.8±5.35 years, and an average length of service of 17.9±2.8 years. The results obtained during the study were compared with a control group (CG) of 46 people (48.37±4.18 years) who had no contact with vibration. The researchers conducted an electroneuromyography (ENMG) with testing of the sensory component of peripheral nerves, with the determination of the F-wave and the registration of somatosensory evoked potentials in the upper and lower extremities on the Neuro-EMG-Micro electroneuromyograph (Neurosoft LLC). The specialists have completed peripheral transcranial magnetic stimulation during median nerve testing.

Results. In afferent conducting structures, there is a decrease in the speed of conducting an impulse along axons on the arms and legs, and a decrease in the amplitude of the action potential on the legs, the transit time of excitation in the popliteal fossa decreases, the excitability of neurons in the cervical and lumbar spine, subcortical structures (the thalamic nuclei zone) and in the somatosensory cortex decreases. In efferent conducting structures, a decrease in the rate of conduction of an impulse along the nerves of the upper and lower extremities, damage to the motor neurons of the primary motor cortex, neurons of the corticospinal tract and at the level of the lumbar and cervical spine was found.

Limitations. A limitation of the study is the fact that transcranial magnetic stimulation was not performed when testing the nerves of the lower extremities.

Conclusion. In patients with vibration disease associated with the combined effects of local and general vibration, a decrease in the rate of pulse conduction along afferent axons in the upper extremities was revealed, and a decrease in the action potential of the nerve trunk in the lower extremities. A violation of the pulse conduction time along the afferent pathways of the lumbar and cervical spine has been established. A slowdown in the activation of neurons of afferent conducting structures in the thalamic region, in the area of the somatosensory cortex, as well as a slowdown in the depolarization of efferent neurons of the primary motor cortex and the corticospinal tract was revealed.

Ethics. The conclusion of the MEС of East Siberian Institute of Medical and Environmental Research — Protocol No. 5 dated 03/21/2013.

Contributions:
Rusanova D.V. — research concept and design, collection and processing of material, writing and formatting of the article, editing;
Lakhman O.L. — research concept and design, editing;
Slivnitsyna N.V. — collection and processing of material, writing an article, editing.
All co-authors — approving the final version of the article and ensuring the integrity of all parts of the article.

Funding. The study had funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 24.01.2025 / Accepted: 23.02.2025 / Published: 07.04.2025

Currently, the demographic situation in Russia can be characterized by a decrease in the birth rate, an increase in mortality, and an increase in the proportion of elderly and senile people. One of the factors influencing the birth rate in the Russian Federation, in addition to socio-economic reasons, is the level of medical care provided to the population, the state of public health, including the level of reproductive health. The main indicators characterizing the state of reproductive health are the fertility rate, the mortality rate, the natural population growth rate, perinatal, infant and maternal mortality, the spread of sexually transmitted infections, the prevalence of genital and extragenital pathology, the frequency of infertility in marriage. In addition, experts estimate the frequency of induced abortions and the prevalence of certain methods of contraception. In Russia, as in the rest of the world, researchers have observed a significant increase in the number of women serving in the armed forces and law enforcement agencies. Performing official duties in law enforcement agencies involves a number of occupational risks that affect the health of employees, including the reproductive function of women. Among the professional factors accompanying official activity in law enforcement agencies, one can single out: irregular working hours, eating disorders, stressful situations, meteorological and environmental factors, work in an unfavorable epidemiological situation, etc. Considering that the organs of the reproductive system are particularly sensitive to adverse environmental factors, factors of the industrial environment, directly or indirectly, through somatic morbidity, can act as pathogenetic causes of disorders in the reproductive sphere. The state of reproductive health of female law enforcement officers is fragmentally sanctified in the Russian and world scientific literature. In the specialized literature, we can find that menstrual disorders, inflammatory diseases of the female genital organs and hyperplastic changes in the endometrium occupy a leading place in the structure of reproductive diseases in female law enforcement officers. Foreign studies have noted a high incidence of cervical cancer, miscarriages and premature birth. The study of the reproductive health of female employees of the internal affairs bodies, the assessment of the contribution and capabilities of departmental healthcare in the prevention of morbidity in this area seem relevant, including from the perspective of improving the demographic situation in the country.

Ethics. The study was conducted in compliance with medical confidentiality.

Contributions:
Shostak D.P. — research concept and design, data collection and processing, text writing;
Fesenko M.A. — research concept and design;
Goncharov A.G. — research concept and design, text writing, editing;
Burmistr A.V. — editing.

Acknowledgement. The authors would like to thank Peter Grigorievich Shostak, the head of the Federal Medical Institution "Ministry of Internal Affairs of the Russian Federation for the Kaliningrad Region", and Liana Dzhambolovna Plieva, an obstetrician-gynecologist for their help in conducting the study.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 21.02.2025 / Accepted: 14.03.2025 / Published: 07.04.202

An increase in recent years in the volume of work on the construction and repair of nuclear facilities for marine equipment has led to an increase in the amount of radioactive waste generated and, consequently, work on their processing, which may contribute to an increase in personnel radiation doses. The study of the qualitative and quantitative characteristics of a complex of production factors that negatively affect personnel when performing work on radioactive waste management is necessary to develop preventive measures aimed at improving working conditions and prolonging professional longevity.

The study aims to explore the working conditions of employees of nuclear shipbuilding and ship repair enterprises when handling radioactive waste.

The researchers assessed the levels of exposure to harmful and(or) hazardous production factors based on materials from the company's production control, a special assessment of working conditions, and field research data. The scientists carried out measurements of the parameters in accordance with certified measurement methods. All measuring instruments used have passed metrological control in a timely manner.

The authors have obtained new data to assess the impact of harmful and(or) dangerous environmental factors of a chemical and physical nature on personnel. The working conditions of the main professional groups are considered harmful and in some cases dangerous due to a number of environmental factors (ionizing radiation, noise, microclimate, light environment). The most radiation-hazardous work takes place at the site for processing liquid and solid radioactive waste, as well as at the site for storing solid radioactive waste.

In the workplaces of personnel during the storage and processing of radioactive waste, the prevailing harmful and(or) dangerous production factors are ionizing radiation, industrial noise, irrational lighting and microclimate. At the same time, non-compliance of illumination levels, noise and microclimate parameters in workplaces with hygienic standards can lead to an increase in the time required to perform radiation-hazardous work and an increase in the individual effective radiation dose received by personnel. Thus, reducing the impact of these factors can be considered a priority for improving working conditions.

Contributions:
Arefieva D.V. — research concept and design, data collection and processing, text writing;
Baltrukova T.B. — research concept and design, editing;
Stepanov V.V. — research concept and design, data collection and processing, text writing;
Kozhukhova N.A. — data collection and processing, writing text;
Shayakhmetova A.A. — data collection and processing.

Funding. The study was carried out within the framework of the State Assignment No. 388-00089-24-00 dated December 29, 2023.

Conflict of interest. The authors declare no conflicts of interest.

Received: 24.01.2024 / Accepted: 24.03.2025 / Published: 07.04.2025

Classification and ranking of potentially hazardous chemical facilities and contaminated territories are urgent and important tasks in the field of risk management and environmental protection. The presented tasks arise in connection with the need to make decisions on increasing control over hazardous production facilities, as well as optimizing resources and reducing negative environmental impacts, which makes it possible to identify facilities with the greatest potential for danger and strengthen control over them, which contributes to improving the safety of employees, society and the environment.

The study aims to substantiate the possibilities of using the method of ranking potentially dangerous chemical and radiation facilities based on literature data to assess their impact on public health and the environment.

The scientists have conducted a systematic review of scientific data to substantiate methodological approaches and criteria necessary for ranking potentially dangerous chemical and radiation facilities in order to assess their risk to public health and the environment from bibliographic databases Scopus, MedLine, Web of Science, PubMed, Cochrane Library, RSCI.

The results of the research have made it possible to determine the specifics of accounting for the impact of industrial facilities on the environment and human health applicable to pilot facilities and territories, the possibilities of ranking activities by risk levels are shown, allowing to identify the most critical sectors and processes requiring special attention and regulation. The approaches to creating a unified information and analytical system that takes into account the impact of the environment on health are substantiated, which will make it possible to purposefully develop comprehensive programs for the prevention of morbidity in the population and assess the impact of harmful combined effects of environmental factors on health. The authors have presented criteria for the preliminary ranking of potential carcinogens (total annual emissions, weight coefficient of carcinogenic effect.

In the course of their work, the scientists showed the possibilities of ranking activities by risk levels, which make it possible to identify the most critical sectors and processes that require special attention and regulation. They also presented criteria for preliminary ranking of potential carcinogens (the amount of total annual emissions, the weight coefficient of the carcinogenic effect.

Ethics. This study did not require the conclusion of an Ethics Committee.

Limitations. Given that this study was conducted on the basis of theoretical literature data, three pilot territories are not sufficient for its practical application. In the future, it is planned to expand the number of objects and territories for ranking.

Contributions:
Ushakova O.V. — research concept and design, data collection and processing, text writing, manuscript preparation;
Evseeva I.S. — concept and design of the research, writing of the text, preparation of the manuscript;
Vodyanova M.A. — data collection and processing, text writing, manuscript preparation;
Sabirova Z.F. — data collection and processing, text writing, manuscript preparation;
Yudin S.M. — the concept and design of research, preparation of the manuscript.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 23.01.2025 / Accepted: 26.02.2025 / Published: 07.04.2025

Brucellosis is a zoonotic infectious disease that remains a serious medical and social problem in many countries, including the Russian Federation. In recent years, specialists in the Republic of Tatarstan have recorded a fivefold increase in the incidence of brucellosis due to the unauthorized import of cattle from regions affected by this disease. The main causative agent is Brucella abortus, but other types of brucella, such as Brucella melitensis, can also cause the disease, which causes a variety of clinical forms and diagnostic difficulties.

The urgency of the problem is caused by an increase in migration of the population and animals, leading to an expansion of epidemic links and an increased risk of transmission of infection.

The article presents an analysis of two clinical cases of professional and non-professional infection with brucellosis by various types of brucella. Both cases have clinical and epidemiological features: in the first case, a slowly progressive lesion of large and small joints, in the other, a severe course with severe intoxication, involvement of the osteoarticular system with the addition of sacroiliitis.

The described cases indicate the emergence of new epidemiological factors, the complexity of clinical and laboratory diagnosis of brucellosis in the context of the relationship of the disease with professional activity.

Mandatory preliminary and periodic medical examinations should be an important condition for the prevention of the disease. To prevent the spread of more pathogenic Brucella species that do not possess strict gostality, timely laboratory diagnostics with the introduction of molecular genetic methods for brucella typing and strengthening of surveillance measures for brucellosis in safe areas are necessary.

Ethics. The conducted research did not require the conclusion of the Ethics Committee.

Contribution:
Gilmullina F.S. — the concept and design of the study, writing the text;
Yakupova F.M. — research concept and design, writing the text;
Garipova R.V. — research concept and design, text writing, editing;
Arkhipov E.V. — research design, text writing, editing;
Isokov A.A. — working with primary material, writing text.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 08.02.2025 / Accepted: 25.03.2025 / Published: 07.04.2025

A review of research in the field of occupational medicine shows that one of the central places in it is occupied by a comprehensive diagnosis of an employee's health status, especially in situations of severe and prolonged stress, which often leads to complete or partial professional burnout. The profession of a medical professional occupies a key place among specialties with a high risk of occupational stress. The consequences of occupational stress are closely related to the threat of developing various diseases of the nervous, cardiovascular, immune and endocrine systems. There is a growing interest in the importance of antibodies to specialized structures of nervous tissue, which are considered as new-generation biomarkers in a number of neurological disorders. A significant number of studies show the role of the cytokine network in the pathogenesis of anxiety and depressive disorders caused by stress.

The study aims to evaluate the serum concentrations of antibodies to regulatory proteins of the nervous tissue, pro- and anti-inflammatory cytokines and their interrelationships in the secondary medical staff to substantiate the early immunochemical indicators of changes in the nervous system.

The authors conducted a laboratory immunological examination of the secondary medical staff of the therapeutic profile and the comparison group. Using enzyme immunoassay in blood serum, the authors determined IgG class antibodies to nervous tissue proteins and the content of proinflammatory cytokines (IL-1β, IL-6, IL-8, TNF-α, IL-4).

In medical workers working under occupational stress, when compared with the comparison group, the authors revealed increased levels of AВ to nervous tissue proteins (S-100, Hol-R, GABA-R, DA-R, Ser-R), a change in cytokine balance characterized by hyperactivation of the proinflammatory immune response (IL-1β, IL-8) against the background of increased individual immunoreactivity in 75% of cases. Correlation analysis showed the presence of a relationship between AB to DA and IL-1β receptors.

The results obtained indicate a more likely risk of developing neuroimmune inflammation in medical staff and allow us to identify the most informative biomarkers (AT to DA-R, IL-1β, IL-8) for diagnosing disorders in the nervous system.

Limitations. The disadvantage of this work is the small number of employees.

Ethics. The study was conducted in compliance with ethical standards in accordance with the Helsinki Declaration of the World Medical Association. The work was approved by the local Ethics committee of the East-Siberian Institute of Medical and Ecological Research (Protocol No. 5 dated 03/21/2023).

Contributions:
Boklazhenko E.V. — research concept and design, data collection and processing, text writing;
Bodienkova G.M. — research concept and design, text writing, editing.

Funding. The work was carried out at the expense of financial resources allocated within the framework of the State Assignment of the East-Siberian Institute of Medical and Ecological Research.

Conflict of interest. The authors declare no conflict of interest.

Received: 19.02.2025 / Accepted: 20.02.2025 / Published: 07.04.2025

The widespread use of vanadium and its compounds in various fields of industry causes an increase in its emissions into the environment. Workers of metallurgical enterprises and residents of nearby territories are the most susceptible to its influence. Despite its known therapeutic effects, reports of its negative effects require a more detailed study of the toxicodynamic properties of vanadium. At the same time, changes in the blood metabolome caused by the intake of vanadium have not previously been described in the literature. The results of this study will serve as a starting point in the creation of a diagnostic method for detecting disorders caused by exposure to vanadium compounds.

The study aims to identify metabolic changes in rat blood in an acute toxicological experiment with a single intraperitoneal administration of sodium metavanadate.

The scientists conducted a study on 22 male Wistar rats divided into three groups: rats injected with NaVO₃ solution at a concentration of 11.61 mg/kg (n=8); rats injected with NaVO₃ solution at a concentration of 18.40 mg/kg (n=8); control group (n=6). A semi-quantitative metabolomic blood test was performed using liquid chromatography mass spectrometry.

A metabolomic blood test showed the effect of vanadium on lipid metabolism, among which in the groups exposed to NaVO₃, the authors found a decrease in the level of 3 glycerophospholipids, 1 short-chain acylcarnitine, 1 sphingolipid, 1 glycerolipid and an increase in the content of 2 long-chain acylcarnitines, while among tetrapyrroles they found an increase in bilirubin.

The results of a metabolic study of rat blood after a single exposure to pentavalent vanadium in the form of a NaVO₃ solution at concentrations of 11.61 and 18.40 mg/kg indicate the presence of changes in the animal body associated with the metabolism of lipids and tetrapyrroles. Based on them, under the action of vanadium, hepatotoxicity occurs: activation of lipolysis processes and disruption of energy metabolism due to changes in the process of β-oxidation.

Limitations. The level of metabolites in the blood of animals was determined semi-quantitatively.

Ethics. The study was approved at a meeting of the Local Ethics Committee of the Yekaterinburg Medical and Scientific Center for the Prevention and Health Protection of Industrial Workers of Rospotrebnadzor (Protocol No. 1/2 dated 06/09/2022).

Contributions:
Unesikhina M.S. — data collection and processing, text writing, editing;
Chemezov A.I. — research concept and design, data collection and processing, text writing, editing;
Sutunkova M.P. — research concept and design, editing;
Minigalieva I.A. — concept and design of research, editing.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflicts of interest.

Received: 23.01.2025 / Accepted: 26.02.2025 / Published: 07.04.2025

Vibration disease (VD) is an occupational disease that develops with prolonged exposure to industrial vibrations of different frequencies. Previously, the effect of vibration disease on human aging was shown, measured on the basis of physiological indicators. Measuring telomere length is the most common indicator of a person's biological age, which is believed to reflect the difference in a person's aging rate. Telomeres are non-coding regions of heterochromatin and serve to protect the ends of chromosomes from sticking together and from gene erosion.

The study aims to estimate the biological age of employees suffering from vibration disease by determining the relative length of telomeres (RLT).

To conduct the study, the specialists received biomaterials from 51 people aged 35 to 60 years, who were examined at the Ufa Research Institute of Occupational Health and Human Ecology. The study participants were divided into groups depending on the diagnosis of vibration disease and the type of vibration exposure. Determination of the relative length of telomeres was carried out using the real-time polymerase chain reaction (RT-PCR) method. The researchers performed statistical analysis using the scipy.stats package in Python.

The researchers found a statistically significant decrease in the relative telomere length in the group of workers with vibration disease compared with healthy workers. An analysis of the relative telomere length in workers exposed to various types of vibration revealed a statistically significant decrease in telomere length in workers exposed to general vibration compared with other groups studied.

The development of vibration disease is associated with a statistically significant decrease in the average relative telomere length. This biomarker also shows differences depending on the nature of exposure: general vibration is associated with a greater decrease in the relative length of telomeres than local vibration.

Limitations. The disadvantages of the work include the lack of data on working conditions. It was not possible to obtain data on the magnitude of the impact of vibration, which did not allow quantifying its effect on the development of vibration disease and on the relative length of telomeres. Also, the work does not take into account the accompanying harmful production factors, since their heterogeneity and small sample size for each factor did not allow for statistical analysis. The disadvantages include the lack of additional tests, such as the level of cortisol and other hormones associated with the stress response. It is also worth noting the small size of the sample under study, which did not allow a regression analysis to compare the effects of gender, age, and other characteristics on relative telomere length and vibration disease.

Ethics. The study was approved by the bioethics committee of Ufa Research Institute of Occupational Medicine and Human Ecology, extract from protocol No. 02-04 dated 18.04.2024. Informed consent was obtained from all participants.

Contributions:
Karimov D.D. — data collection and processing, experiments, statistical processing, writing and editing the text;
Shaykhlislamova E.R. — study concept and design, data collection and processing, text editing and approval;
Mukhammadieva G.F. — data collection and processing, text writing and editing;
Karimov D.O. — study concept and design, statistical processing, text editing and approval;
Kudoyarov E.R. — experiments, text editing;
Gizatullina A.A. — experiments, text editing;
Smolyankin D.A. — experiments, text editing.

Funding. The study had no funding.

Conflict of interest. The authors declare no conflict of interest.

Received: 16.10.2024 / Accepted: 23.02.2025 / Published: 07.04.2025